<sup>18</sup>F‐FDG PET in detection of primary age‐related tauopathy (PART) – Is there a role? Insights from an imaging‐pathology correlation study
FDG-PET hypometabolism worsens with Braak NFT stage. FDG-PET detects mild lateral temporal lobe hypometabolism in PART alone. PART alone has a minimal effect on medial temporal lobe hypometabolism. Medial temporal hypometabolism is worse in PART with TDP-43 and especially AGD. The presence of LBD contributes to parietal hypometabolism on FGD-PET in PART.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Keith A. Josephs (ORCID: https://orcid.org/0000-0003-2930-8634)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Jonathan Graff‐Radford
- Ronald Carl Petersen (ORCID: https://orcid.org/0000-0002-8178-6601)
- Nha Trang Thu Pham
- Anna Lavrova (ORCID: https://orcid.org/0009-0001-7521-7082)
- Aivi T. Nguyen (ORCID: https://orcid.org/0000-0003-1809-9451)
- Ruth A. Ross
- Bradley F. Boeve (ORCID: https://orcid.org/0000-0002-4153-8187)
- Cynthia J. Vernon
- Kejal Kantarci (ORCID: https://orcid.org/0000-0002-8001-2081)
- Jennifer L. Whitwell (ORCID: https://orcid.org/0000-0001-6914-1563)
- David S. Knopman
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/alz.70568
- Citations
- 2
- Primary Topic
- Cerebrovascular and Carotid Artery Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Institute on Aging