Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of <i>Roseburia intestinalis</i>
Inflammatory bowel disease (IBD) is marked by severe colonic inflammation and oxidative stress-induced tissue damage, often accompanied by gut microbiota dysbiosis. Probiotics have recently been recognized as promising therapeutic agents for IBD. Herein, we examined the modulatory effects of orally administered metal-organic framework (MOF) nanozyme MOF-818 on gut microbiota in a mouse model of IBD. Oral treatment with MOF-818 significantly alleviated IBD symptoms, reduced intestinal oxidative damage, and favorably altered the gut microbiota composition. Notably, MOF-818 selectively enhanced the proliferation of <i>Roseburia intestinalis</i> (<i>R. intestinalis</i>). Further analyses showed that MOF-818 significantly upregulated bacterial division-related genes (<i>ftsZ, ftsE</i>) in <i>R. intestinalis</i> while genes associated with ATP synthesis (<i>atpA, atpD</i>) were also highly expressed, boosting energy production to support rapid cell division and proliferation. These findings underscore the biofunctional role of MOF-818 as an active modulator of the gut microflora rather than a passive therapeutic agent, which highlights its significant synergistic potential with probiotics and lays a theoretical foundation for the future application of MOF-based materials in combination with probiotics.
Authors
- Bin Xu (ORCID: https://orcid.org/0000-0002-9395-3606)
- Yu Cao (ORCID: https://orcid.org/0000-0002-0129-0199)
- Daiyong Chao (ORCID: https://orcid.org/0009-0001-9582-5368)
- Wenjin Guo (ORCID: https://orcid.org/0000-0002-7679-7138)
- Qingfeng Dong (ORCID: https://orcid.org/0000-0002-7618-6249)
- S. W. K. Yuan (ORCID: https://orcid.org/0000-0002-9818-1609)
- Xinyue Wang (ORCID: https://orcid.org/0000-0002-9192-1803)
- Guang Yang (ORCID: https://orcid.org/0009-0000-3252-8019)
- Lei Su (ORCID: https://orcid.org/0000-0002-8555-3135)
- Shiqian Ding (ORCID: https://orcid.org/0000-0002-0485-8835)
- Xuanting Liu (ORCID: https://orcid.org/0000-0002-2592-3026)
- Shoupeng Fu (ORCID: https://orcid.org/0000-0003-1898-838X)
- Li-Wei Tu (ORCID: https://orcid.org/0000-0001-8462-7203)
- Juxiong Liu
- Huijie Hu (ORCID: https://orcid.org/0000-0002-0030-2346)
Institutions
- Weifang Medical University (CN)
- Jilin University (CN)
- Kerala Veterinary and Animal Sciences University (IN)
- Second Hospital of Shandong University (CN)
- Institute of Zoology (KZ)
- Heilongjiang Bayi Agricultural University (CN)
- Jilin Medical University (CN)
- Second Affiliated Hospital of Jilin University (CN)
- State Key Laboratory of Food Science and Technology (CN)
- Stanford University (US)
Publication Details
- Journal
- ACS Nano
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1021/acsnano.5c09530
- Citations
- 4
- Primary Topic
- Metal-Organic Frameworks: Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing
- Natural Science Foundation of Shandong Province