Metabolic Syndrome and Insulin Resistance Are Associated With Normal‐Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome

In Chinese PCOS patients, normal-range elevations in ALT and AST along with a lower AST/ALT ratio were associated with more severe manifestations of MS components, and ALT was more specific in predicting MS. Moreover, patients with higher ALT and lower AST/ALT ratios tend to exhibit more severe IR, and their ratio is superior to predict IR. The increased ALT and AST were associated with elevated myocardial enzymes, and ALT is the most sensitive indicator of renal impairment. It reinforces the need for PCOS-specific enzyme reference ranges.

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Publication Details

Journal
Clinical Endocrinology
Published
2025-08-19
DOI
https://doi.org/10.1111/cen.70018
Citations
1
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.35

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article

Metabolic Syndrome and Insulin Resistance Are Associated With Normal‐Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome

Jing Cong, Xiaoke Wu, Jiaxing Feng, Rong Luo et al.
1 citations
Clinical Endocrinology
Liver Disease Diagnosis and Treatment
1.35
article

Metabolic Syndrome and Insulin Resistance Are Associated With Normal‐Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome

Jing Cong, Xiaoke Wu, Jiaxing Feng, Rong Luo, Hui He, Hang Ge, Wen Yang, Yang Liu, Qing Xia
article en
1 citations

Abstract

In Chinese PCOS patients, normal-range elevations in ALT and AST along with a lower AST/ALT ratio were associated with more severe manifestations of MS components, and ALT was more specific in predicting MS. Moreover, patients with higher ALT and lower AST/ALT ratios tend to exhibit more severe IR, and their ratio is superior to predict IR. The increased ALT and AST were associated with elevated myocardial enzymes, and ALT is the most sensitive indicator of renal impairment. It reinforces the need for PCOS-specific enzyme reference ranges.

Clinical EndocrinologyVol. 103(6)
Zhejiang Chinese Medical University (CN), First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN), Jiangxi Chest Hospital (CN), Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN), The First People’s Hospital of Lianyungang (CN), First Affiliated Hospital of Zhengzhou University (CN)
Heilongjiang University, National Natural Science Foundation of China, Department of Education, Heilongjiang Province, Heilongjiang University of Chinese Medicine
Openalex Percentile: Top 16%
Liver Disease Diagnosis and Treatment
1.35
DOIOpen Access PDFOpenAlex
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Metabolic Syndrome and Insulin Resistance Are Associated With Normal‐Range Aspartate Aminotransferase, Alanine Aminotransferase, and Their Ratio in Chinese Women With Polycystic Ovary Syndrome — Jing Cong, Xiaoke Wu, et al. · Clinical Endocrinology (2025) | TGRS Research Map | TGRS