Broad‐spectrum antifungal activity of aniline‐modified tavaborole derivatives: insights from molecular docking and bioassays
This study establishes substituted aniline-tavaborole hybrids as highly promising candidates for next-generation agricultural fungicides. The unique LeuRS inhibition mechanism of the designed molecules presents an innovative and effective strategy to counter fungal pathogens, demonstrating substantial potential for crop protection. © 2025 Society of Chemical Industry.
Authors
- Xin‐Ying Zhao
- Veranja Karunaratne
- Yu‐Cheng Gu (ORCID: https://orcid.org/0000-0002-6400-6167)
- Qiang Bian (ORCID: https://orcid.org/0000-0001-8796-4264)
- Zhaoxia Chen (ORCID: https://orcid.org/0009-0007-6317-0612)
- Qiang Sha (ORCID: https://orcid.org/0000-0002-3253-2226)
- Xiao Feng (ORCID: https://orcid.org/0000-0001-8919-6000)
- Gizachew Mulugeta Manahelohe (ORCID: https://orcid.org/0000-0002-6098-9450)
- Ming‐Zhi Zhang (ORCID: https://orcid.org/0000-0002-8439-8989)
- Weihua Zhang (ORCID: https://orcid.org/0000-0003-1994-5306)
- Wang Li (ORCID: https://orcid.org/0000-0002-7771-1105)
- Zhuo He
- Bing Jin (ORCID: https://orcid.org/0009-0009-5567-4794)
- Enyu Jiang
Institutions
- University of Peradeniya (LK)
- Nanjing Agricultural University (CN)
- Nankai University (CN)
- Tianjin Economic-Technological Development Area (CN)
- Syngenta (United Kingdom) (GB)
- University of Gondar (ET)
Publication Details
- Journal
- Pest Management Science
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1002/ps.70143
- Primary Topic
- Plant Disease Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China