Chronic ethanol exposure reduces resting state functional connectivity and regional synchrony in male rats
Chronic alcohol exposure and withdrawal decreases baseline functional connectivity and local synchrony in male rats which is not affected by HDAC inhibition. Future studies should examine the effects of alcohol on resting state connectivity in female rats as well as in voluntary alcohol consumption paradigms. Understanding baseline differences may open new therapeutic avenues in alcohol abuse and AUD to restore typical resting state connectivity.
Authors
- A. Leslie Morrow (ORCID: https://orcid.org/0000-0003-4441-956X)
- Melissa A. Herman (ORCID: https://orcid.org/0000-0002-7260-3439)
- Woomi Ban
- Elizabeth J. Crofton (ORCID: https://orcid.org/0000-0001-5538-6658)
- Tzu-Wen Winnie Wang
- Sung‐Ho Lee (ORCID: https://orcid.org/0000-0003-2111-5504)
- Yen-Yu Ian Shih
Institutions
- University of North Carolina at Chapel Hill (US)
- Emmanuel College - Massachusetts (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1007/s00213-025-06881-0
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Alcohol Abuse and Alcoholism
- National Institute of General Medical Sciences
- Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill