Distinct platelet transcriptomic heterogeneity in respiratory illnesses and modulation by corticosteroids and immune antibody treatments
A systematic investigation of platelet transcriptomic heterogeneity in respiratory infections, combined with the delineation of its therapeutic modulation by dexamethasone and tocilizumab, advances the understanding of platelet involvement in immune-thrombotic dysregulation and provides a foundation for exploring potential therapeutic targets.
Authors
- Kaifeng Jin (ORCID: https://orcid.org/0000-0001-9867-6516)
- Wenjun Song (ORCID: https://orcid.org/0000-0002-0165-7894)
- Qingqing Wang (ORCID: https://orcid.org/0000-0002-0415-0052)
Institutions
- Zhejiang Lab (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s12967-025-06845-0
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program
- Natural Science Foundation of Zhejiang Province