GALNT7 Stratifies dMMR/MSI Colorectal Cancer into Distinct Molecular Subsets Associated with Prognosis and PD-L1 Expression
We identified glycosyltransferases with altered expression depending on MMR/MSI status. Our findings indicate the existence of two molecularly defined subtypes within dMMR/MSI colorectal cancers based on GALNT7 expression, characterized by differential tumor cell PD-L1 levels and distinct survival outcomes.
Authors
- Kosaku Mimura (ORCID: https://orcid.org/0000-0003-2565-154X)
- Zenichiro Saze (ORCID: https://orcid.org/0000-0003-2188-0951)
- Shun Chida
- Tomoyuki Momma (ORCID: https://orcid.org/0000-0002-2911-5800)
- Hirokazu Okayama (ORCID: https://orcid.org/0000-0003-0966-4746)
- Akira Matsuishi
- Shotaro Nakajima (ORCID: https://orcid.org/0000-0002-9339-3792)
- Motonobu Saito (ORCID: https://orcid.org/0000-0001-5072-3520)
- Ryo Kanoda
- Wataru Sakamoto (ORCID: https://orcid.org/0000-0001-7045-5834)
- Misato Ito (ORCID: https://orcid.org/0000-0001-8004-6487)
- Takuro Matsumoto (ORCID: https://orcid.org/0000-0001-5589-8573)
- Koji Kono (ORCID: https://orcid.org/0000-0003-0106-2767)
- Hiroya Suzuki
- Yuya Maruyama
- Katsuharu Saito
Institutions
- Fukushima Medical University (JP)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0270
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Japan Society for the Promotion of Science