Dietary <scp>BCAA</scp> supplementation counteracts the beneficial effects of long‐term aerobic exercise against obesity and associated metabolic disorders by suppressing <scp>FGF21</scp> expression
Long-term aerobic exercise mitigates obesity and associated metabolic disorders by reducing BCAA abundances and subsequently FGF21 induction. The causal relationship between dietary BCAA intake and the anti-obesity effects of exercise provides novel insight into the metabolic interplay between exercise and BCAAs, underscoring the potential of integrating exercise with precise nutrient modulation as an effective strategy to improve metabolic health.
Authors
- Haipeng Sun (ORCID: https://orcid.org/0000-0003-2128-3209)
- Lei Gao (ORCID: https://orcid.org/0009-0008-8887-5296)
- Chengnan Zhang (ORCID: https://orcid.org/0009-0003-7357-1680)
- Junqiang Qiu (ORCID: https://orcid.org/0000-0001-8313-9216)
- Mingyue Lu
- Yajin Liu
- Xuejiao Zhang (ORCID: https://orcid.org/0000-0002-6139-1418)
- Zhenqiang Song (ORCID: https://orcid.org/0009-0000-4853-1482)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-1313-9381)
- Peiyuan Li (ORCID: https://orcid.org/0000-0001-5543-2298)
Institutions
- Nanjing Normal University (CN)
- Tianjin Infectious Diseases Hospital (CN)
- Tianjin Medical University (CN)
- Beijing Sport University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1111/dom.70039
- Citations
- 2
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Tianjin City
- National Key Research and Development Program of China