Genome‐Wide <scp>DNA</scp> Methylation Study Reveals Specific Signatures in the Affected Arterial Tissue of Patients With Giant Cell Arteritis
Our study identified GCA-specific DNA methylation signatures in arterial tissue, revealing disrupted inflammatory and vascular pathways and suggesting the involvement of exhausted T cells in this condition. These findings offer new insights into GCA pathogenesis and provide new potential targets for the treatment of this debilitating disease.
Authors
- Laura C. Terrón‐Camero (ORCID: https://orcid.org/0000-0002-9746-8800)
- Alberto Cavazza (ORCID: https://orcid.org/0009-0006-9934-1666)
- Santos Castañeda (ORCID: https://orcid.org/0000-0002-7748-853X)
- Miguel Ángel González-Gay (ORCID: https://orcid.org/0000-0002-7924-7406)
- Sébastien Fontana (ORCID: https://orcid.org/0000-0002-7414-2648)
- Ana Márquez (ORCID: https://orcid.org/0000-0001-9913-7688)
- Píetro Lió (ORCID: https://orcid.org/0000-0002-0540-5053)
- Nicolò Pipitone (ORCID: https://orcid.org/0000-0002-2002-7185)
- Stefania Croci (ORCID: https://orcid.org/0000-0002-8622-0439)
- Javier Martı́n (ORCID: https://orcid.org/0000-0002-2202-0622)
- Giuliana Guggino (ORCID: https://orcid.org/0000-0003-2479-6958)
- Elkyn Estupiñán‐Moreno (ORCID: https://orcid.org/0000-0002-5818-4389)
- Martina Bonacini (ORCID: https://orcid.org/0000-0002-6830-6781)
- David Saadoun (ORCID: https://orcid.org/0000-0003-3628-9996)
- Francesco Muratore (ORCID: https://orcid.org/0000-0003-0362-2668)
- Gonzalo Borrego‐Yaniz (ORCID: https://orcid.org/0000-0003-1474-2884)
- Lourdes Ortiz‐Fernández (ORCID: https://orcid.org/0000-0002-0247-4280)
- Alessandro Rossi (ORCID: https://orcid.org/0000-0002-6719-3324)
- Carlo Salvarani (ORCID: https://orcid.org/0000-0003-3708-3148)
Institutions
- University of Modena and Reggio Emilia (IT)
- Universidad de Cantabria (ES)
- University of Cambridge (GB)
- Sorbonne Université (FR)
- Josep Carreras Leukaemia Research Institute (ES)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Bridge University (SS)
- Pitié-Salpêtrière Hospital (FR)
- Hospital Universitario Fundación Jiménez Díaz (ES)
- Hospital Universitario de La Princesa (ES)
- University of Palermo (AR)
- Hôpital Charles-Foix (FR)
- Instituto de Parasitología y Biomedicina "López - Neyra" (ES)
- University of Palermo (IT)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1002/art.43358
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad de Granada