Resolving tumor microenvironment heterogeneity to forecast immunotherapy response in triple-negative breast cancer through multi-scale analysis
This study highlighted the cellular heterogeneity of TNBC and identified ISG15 as a candidate biomarker potentially associated with treatment response. The ISG15-based predictive system might provide a robust framework for predicting ICI response.
Authors
- Jiangrui Chi
- Yi Sun (ORCID: https://orcid.org/0000-0002-4077-0187)
- Nan Wang (ORCID: https://orcid.org/0000-0003-2006-9999)
- Shihao Sun (ORCID: https://orcid.org/0000-0002-1701-8114)
- Shuang Chen
- Lin Li (ORCID: https://orcid.org/0000-0003-4597-2017)
- Xinxing Wang (ORCID: https://orcid.org/0000-0003-1650-3297)
- Kaiyuan Li (ORCID: https://orcid.org/0009-0003-6370-1031)
- Ge Zhang (ORCID: https://orcid.org/0009-0002-7012-2655)
- Yijia Xu
Institutions
- First Affiliated Hospital of Henan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Henan Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3389/fonc.2025.1538574
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00