The gut microbiota protein BOC1 exhibits immune checkpoint inhibitor-like activity by inhibiting myeloid-derived suppressor cell differentiation
The immunostimulatory properties of BOC1 observed <i>in vitro</i> are compatible with an ICI-like behavior of this bacterial protein. Given that neither the CD200 protein nor the anti-CD200 antibody is able to compete with BOC1 for binding to CD200R1, and as supported by AlphaFold modeling predictions, CD200 and BOC1 might target different regions of CD200R1.
Authors
- Antonietta Cultrone (ORCID: https://orcid.org/0009-0000-4706-9599)
- Caroline Matondo
- Laurent Chêne
- Francesco Strozzi (ORCID: https://orcid.org/0000-0002-6845-6982)
- María Lucía Orsini Delgado (ORCID: https://orcid.org/0000-0003-4655-1695)
- Laureen Bardouillet
- Valentine Thomas
Institutions
- Enterome (France) (FR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1607543
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00