Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy
We reveal novel insights into the heterogeneity and functional diversity of B cells in patients with PMN. And revealed distinct roles for subgroup 0 plasma cells and B10 Breg cells in the pathogenesis of PMN. Furthermore, targeting B cells, such as galectin-9, presents promising opportunities for modulating the immune response in patients with PMN.
Authors
- Huijuan Mao (ORCID: https://orcid.org/0000-0001-7410-1486)
- Hongwei Liang (ORCID: https://orcid.org/0009-0000-4779-1557)
- Yangfan Wu
- Ying‐Xian Pan (ORCID: https://orcid.org/0000-0002-4006-8304)
- Fang Lu (ORCID: https://orcid.org/0000-0002-8927-2437)
- Yanggang Yuan (ORCID: https://orcid.org/0000-0003-2764-9486)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-1210-8735)
- Qing Li (ORCID: https://orcid.org/0000-0002-5580-1011)
- Changying Xing
- Honglei Guo (ORCID: https://orcid.org/0000-0002-3471-2407)
- Shiyi Chen (ORCID: https://orcid.org/0000-0002-2913-4497)
- Hua Shu (ORCID: https://orcid.org/0000-0002-4131-3551)
- Simeng Liu (ORCID: https://orcid.org/0009-0008-6865-1340)
- Suyan Duan (ORCID: https://orcid.org/0009-0003-6529-3801)
- Lin Wu
Institutions
- China Pharmaceutical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1622395
- Citations
- 1
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- “333 Project” of Jiangsu Province
- Chunhui Project Foundation of the Education Department of China