Association between the depression and cardiovascular risk in arthritis patients: a prospective cohort study from the CHARLS database
Depression linearly increases CVD risk in arthritis patients, with systemic inflammation selectively potentiating this association in depressed individuals. The diabetes-depression-CVD interaction highlights shared pathophysiological pathways. These findings underscore the imperative for integrated clinical strategies targeting both psychological health and inflammatory pathways to reduce cardiovascular morbidity in arthritis populations.
Authors
- Xianglin Yang (ORCID: https://orcid.org/0000-0002-5299-0427)
- Zhenan Qu
- Xiaoyuan Tian (ORCID: https://orcid.org/0000-0002-4418-4206)
- Bocheng Zhang (ORCID: https://orcid.org/0000-0003-1084-4947)
- Ying Cao (ORCID: https://orcid.org/0009-0004-0303-9995)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Affiliated Zhongshan Hospital of Dalian University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3389/fimmu.2025.1590483
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province