SPINK1 facilitates tumor progression via the EGFR/JAK/STAT3 axis in oral squamous cell carcinoma: insights from single-cell RNA sequencing
SPINK1 has been established as a novel therapeutic target in OSCC, with its dual role in tumorigenesis and immune modulation providing a molecular foundation for developing targeted therapeutic modalities and precision oncology strategies.
Authors
- Zhangui Tang (ORCID: https://orcid.org/0000-0001-9197-4035)
- Mingyan Bao
Institutions
- Central South University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3389/fonc.2025.1585277
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China