Individualized treatment of nasopharyngeal carcinoma with lung metastasis in an elderly patient: A case report

Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy, particularly in southern China, with distant metastasis posing significant treatment challenges, particularly in elderly patients. This case report details the successful management of a 90-year-old male with NPC and lung metastasis. The patient underwent intensity-modulated radiotherapy for the nasopharyngeal tumor (70 Gy/35 fractions) with concurrent oral capecitabine, followed by stereotactic body radiotherapy (60 Gy/12 fractions) and immunotherapy (tislelizumab) for progressive lung lesions. Maintenance therapy with capecitabine was continued and the patient achieved stable disease with minimal adverse effects. This case highlights the efficacy of individualized multimodal therapy, including precision radiotherapy, chemotherapy and immunotherapy, in an elderly patient with NPC with metastasis, offering a potential framework for similar cases.