Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy
We identified hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p as differentially expressed in placenta and circulating levels associated with insulin secretion in pregnancy. Hsa-miR-199a-3p may regulate insulin secretion by modulating the expression of E-cadherin and components of the Notch signaling pathway; hsa-miR-3150b-3p may influence glucose-induced insulin secretion through interaction with phospholipase A2.
Authors
- Pierre‐Étienne Jacques (ORCID: https://orcid.org/0000-0002-3961-294X)
- Andrea G. Edlow (ORCID: https://orcid.org/0000-0003-2915-5949)
- S. Ananth Karumanchi (ORCID: https://orcid.org/0000-0002-2281-6831)
- Catherine Allard (ORCID: https://orcid.org/0000-0002-8829-4984)
- José C. Florez (ORCID: https://orcid.org/0000-0002-1730-9325)
- Marie‐France Hivert (ORCID: https://orcid.org/0000-0001-7752-2585)
- Frédérique White (ORCID: https://orcid.org/0000-0002-3442-0033)
- Kristin Ardlie (ORCID: https://orcid.org/0000-0003-4272-6283)
- François Aguet (ORCID: https://orcid.org/0000-0001-9414-300X)
- Luigi Bouchard (ORCID: https://orcid.org/0000-0002-7852-0722)
- Amélie Taschereau (ORCID: https://orcid.org/0000-0001-8046-1322)
- Camille Elise Powe (ORCID: https://orcid.org/0000-0002-7060-7778)
Institutions
- Broad Institute (US)
- Cedars-Sinai Medical Center (US)
- Université de Sherbrooke (CA)
- Harvard University (US)
- Centre Hospitalier Universitaire de Sherbrooke (CA)
- Massachusetts General Hospital (US)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean (CA)
- Harvard Pilgrim Health Care (US)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.3389/fendo.2025.1622500
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé