Bifidobacterium species associated with breastfeeding alleviate neonatal hyperbilirubinaemia via the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulation axis
The results indicate that Bifidobacterium species associated with breastfeeding can prevent neonatal hyperbilirubinemia by regulating the gut microbiota-α-linolenic and linoleic acid metabolism-enterohepatic circulation axis, increasing gut metabolites arachidonic acid and docosahexaenoic acid, and reducing the enterohepatic circulation of bilirubin. Video Abstract.
Authors
- Min Guo (ORCID: https://orcid.org/0000-0003-1722-2163)
- Rui Xiao
- Chunxiu Lin (ORCID: https://orcid.org/0000-0002-5403-8253)
- Gang Wang (ORCID: https://orcid.org/0009-0003-5202-2025)
- Yugui Lin (ORCID: https://orcid.org/0000-0003-3158-2173)
- Hao Zhang
- Wei Chen (ORCID: https://orcid.org/0000-0003-3348-4710)
Institutions
- Jiangnan University (CN)
- Shenzhen University (CN)
- Zhongshan People's Hospital (CN)
- Zhongshan Hospital (CN)
- Boai Hospital of Zhongshan (CN)
- State Key Laboratory of Food Science and Technology (CN)
- Wuxi Institute of Technology (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s40168-025-02190-y
- Citations
- 5
- Primary Topic
- Neonatal Health and Biochemistry
- Type
- article
- Field-Weighted Citation Impact
- 17.47
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities