Matrix stiffness induced gallbladder fibroblasts activation and paracrine SEMA7A promotes gallbladder cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating AKT/p300 signalling
Our findings demonstrate a complex stiffness/SEMA7A/integrin β1/AKT/p300 cascade mediating reciprocal interactions between GFs and GBC cells, offering a potential therapeutic target for patients with GBC.
Authors
- Enxiao Li
- Yinying Wu (ORCID: https://orcid.org/0000-0003-3075-800X)
- Yangwei Fan (ORCID: https://orcid.org/0000-0001-8935-9113)
- Yu Shi (ORCID: https://orcid.org/0000-0001-8962-0975)
- Xuyuan Dong (ORCID: https://orcid.org/0000-0003-2037-7852)
- Huanhuan Wang (ORCID: https://orcid.org/0009-0008-1759-7209)
- Hao Wang (ORCID: https://orcid.org/0000-0001-7252-2674)
- Danfeng Dong (ORCID: https://orcid.org/0000-0001-8539-8908)
- Liankang Sun (ORCID: https://orcid.org/0000-0002-4980-8460)
- Hanqi Li (ORCID: https://orcid.org/0009-0001-8242-3773)
- Ruida Yang
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s13062-025-00683-2
- Citations
- 1
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities