EVA1A facilitates glycolysis in esophageal squamous cell carcinoma to boost PLAU histone lactylation and dampen CD8 <sup>+</sup> T cell activity
High EVA1A expression enhances glycolysis in ESCC, and the resulting lactate further induces H4K12la lactylation and promotes PLAU expression. This inhibits the anti-tumor activity of CD8<sup>+</sup> T cells, suggesting that EVA1A has potential as a therapeutic target for ESCC.
Authors
- Yang Xu (ORCID: https://orcid.org/0000-0002-3989-1184)
- Chao Ren
- Zeyu Wang (ORCID: https://orcid.org/0000-0001-7314-7888)
- Shuyi Li (ORCID: https://orcid.org/0000-0002-4040-6430)
- Jing Wang (ORCID: https://orcid.org/0009-0007-2622-1839)
- Jin Xia
- Heng Cao
- Yuan Yuan
Institutions
- Prevention Institute (US)
- Anyang Tumor Hospital (CN)
Publication Details
- Journal
- Expert Review of Clinical Immunology
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1080/1744666x.2025.2545904
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00