The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells
Our findings indicate that TZPD, with its multifaceted role, has beneficial effects on cardiac cells by positively modulating β-ARs signaling and glucose metabolism rather than on-target receptor action. Furthermore, we demonstrated how TZPD can engage the different targets with distinct signaling motifs at the sarcolemma.
Authors
- Belma Turan (ORCID: https://orcid.org/0000-0003-2583-9294)
- Mehmet Altay Ünal (ORCID: https://orcid.org/0000-0001-8607-5043)
- Kamil Can Akçalı (ORCID: https://orcid.org/0000-0002-7816-6938)
- Zeynep Büşra Aksoy (ORCID: https://orcid.org/0000-0002-8288-0974)
- Dunya Aydos (ORCID: https://orcid.org/0000-0003-3574-7844)
Institutions
- Ankara University (TR)
- Lokman Hekim Üniversitesi (TR)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12933-025-02828-z
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu