Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study
Admission peak troponin-I is significantly associated with 60-day mortality in patients with sepsis or ARDS. This association was distinctly driven by the hypoinflammatory subphenotype.
Authors
- Carolyn M. Hendrickson (ORCID: https://orcid.org/0000-0003-4662-2385)
- Vern Eric Kerchberger (ORCID: https://orcid.org/0000-0002-0342-1965)
- Pablo Sanchez (ORCID: https://orcid.org/0000-0002-6324-5086)
- Bruno Evrard (ORCID: https://orcid.org/0000-0003-1829-4927)
- Julie A. Bastarache (ORCID: https://orcid.org/0000-0003-0458-6507)
- Manoj V. Maddali (ORCID: https://orcid.org/0000-0001-5149-0247)
- Carolyn S. Calfee (ORCID: https://orcid.org/0000-0001-9208-6865)
- Kathleen D. Liu (ORCID: https://orcid.org/0000-0003-4891-8649)
- Angela J. Rogers (ORCID: https://orcid.org/0000-0001-6969-6200)
- Sarah N. Obeidalla (ORCID: https://orcid.org/0009-0004-0832-1527)
- Kirsten N. Kangelaris (ORCID: https://orcid.org/0000-0001-8152-994X)
- A. R. Moore (ORCID: https://orcid.org/0000-0001-8040-2576)
- Michael A. Matthay
Institutions
- San Francisco General Hospital (US)
- Inserm (FR)
- University of California, San Francisco (US)
- Hôpital Dupuytren (FR)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Critical Care
- Published
- 2025-08-19
- DOI
- https://doi.org/10.1186/s13054-025-05613-2
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Thoracic Society
- China Scholarship Council
- National Institutes of Health