Human papillomavirus, human immunodeficiency virus, and esophageal squamous cell carcinoma in South Africa: a study of prevalence, co-infection, and risk factors
While no direct association between HIV and HPV in ESCC was found, the high prevalence of high-risk HPV, particularly HPV16 and HPV18, highlights the need for further research. Given South Africa's burden of HIV and HPV, larger multicenter studies are essential to better understand viral contributions to esophageal carcinogenesis.
Authors
- Sikhumbuzo Z. Mbatha
- Michelle McCabe (ORCID: https://orcid.org/0000-0002-5066-1451)
- Rodney Hull (ORCID: https://orcid.org/0000-0002-2001-3453)
- Benny Mosoane (ORCID: https://orcid.org/0000-0002-5588-3221)
- Portia Nevhungoni
- Botle Precious Damane (ORCID: https://orcid.org/0000-0003-3060-5572)
- Zodwa Dlamini (ORCID: https://orcid.org/0000-0002-8012-3646)
- Dakalo Ramali
- Tania Maphosho
Institutions
- National Health Laboratory Service (ZA)
- South African Medical Research Council (ZA)
- Tshwane University of Technology (ZA)
- Beatson West of Scotland Cancer Centre (GB)
- Steve Biko Hospital (ZA)
- Precision Research (United States) (US)
- University of Pretoria (ZA)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fonc.2025.1634565
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- South African Medical Research Council
- Medical Research Council