Pancreatic hepatoid adenocarcinoma with neuroendocrine differentiation and elevated AFP: a case report

Elevated serum AFP levels may be a crucial indicator for preoperative pancreatic HAC diagnosis. Additionally, pancreatic HAC has unique histological and immunophenotypic characteristics. However, neuroendocrine differentiation complicates diagnosis and treatment. Therefore, complete surgical resection is the optimal treatment option for this condition.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-08-18
DOI
https://doi.org/10.3389/fonc.2025.1652925
Primary Topic
Neuroblastoma Research and Treatments
Type
article
Field-Weighted Citation Impact
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article

Pancreatic hepatoid adenocarcinoma with neuroendocrine differentiation and elevated AFP: a case report

Zhenqing Yang, Xiaowei Zhang, Ting Li
Frontiers in Oncology
Neuroblastoma Research and Treatments
article

Pancreatic hepatoid adenocarcinoma with neuroendocrine differentiation and elevated AFP: a case report

Zhenqing Yang, Xiaowei Zhang, Ting Li
article en

Abstract

Elevated serum AFP levels may be a crucial indicator for preoperative pancreatic HAC diagnosis. Additionally, pancreatic HAC has unique histological and immunophenotypic characteristics. However, neuroendocrine differentiation complicates diagnosis and treatment. Therefore, complete surgical resection is the optimal treatment option for this condition.

Frontiers in OncologyVol. 15
Wenzhou Medical University (CN), Zigong First People's Hospital (CN), Dongyang People's Hospital (CN)
Openalex Percentile: Top 69%
Neuroblastoma Research and Treatments
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Pancreatic hepatoid adenocarcinoma with neuroendocrine differentiation and elevated AFP: a case report — Zhenqing Yang, Xiaowei Zhang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS