Aquaporin 2 is differentially expressed in granulosa cells of various stages of human follicles and is regulated by luteinizing hormone
This study provides the first evidence for the mechanisms by which AQP2 influences follicular growth and FF formation, highlighting LH-driven, ERK1/2-dependent regulation of AQP2. These findings offer new insights into the ovarian microenvironment and identify potential therapeutic targets for follicle growth disorders.
Authors
- Zetong Zheng
- Xiubing Zhang (ORCID: https://orcid.org/0009-0000-9147-3089)
- Lingli Long (ORCID: https://orcid.org/0000-0001-9118-2978)
- Simin Liu (ORCID: https://orcid.org/0000-0003-2098-3844)
- Minghui Chen (ORCID: https://orcid.org/0000-0001-5742-0450)
- Yubin Li (ORCID: https://orcid.org/0000-0002-3377-741X)
- Jifan Tan (ORCID: https://orcid.org/0000-0002-1589-3599)
- Canquan Zhou (ORCID: https://orcid.org/0000-0001-6549-8733)
- Yangxing Wen
Institutions
- Sun Yat-sen University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fcell.2025.1647476
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00