Case Report: Carcinosarcoma of the common bile duct: a rare case report with literature review

Carcinosarcoma of the common bile duct is an exceedingly rare and highly aggressive malignancy with uncertain therapeutic outcomes. We present a case of a 70-year-old Asian female presenting with progressive jaundice. Contrast-enhanced computed tomography (CT) identified a tumor in the common bile duct. The patient underwent successful radical pancreaticoduodenectomy, and postoperative histopathological analysis confirmed carcinosarcoma with predominant sarcomatoid differentiation. This report underscores the diagnostic challenges and therapeutic considerations for this rare entity, emphasizing the critical role of pathological confirmation.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-08-18
DOI
https://doi.org/10.3389/fonc.2025.1642467
Primary Topic
Metastasis and carcinoma case studies
Type
article
Field-Weighted Citation Impact
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article

Case Report: Carcinosarcoma of the common bile duct: a rare case report with literature review

Julia Lou, Haoyu Fang, Kun Liu, Zhiwei Hu et al.
Frontiers in Oncology
Metastasis and carcinoma case studies
article

Case Report: Carcinosarcoma of the common bile duct: a rare case report with literature review

Julia Lou, Haoyu Fang, Kun Liu, Zhiwei Hu, A Ru-La
article en

Abstract

Carcinosarcoma of the common bile duct is an exceedingly rare and highly aggressive malignancy with uncertain therapeutic outcomes. We present a case of a 70-year-old Asian female presenting with progressive jaundice. Contrast-enhanced computed tomography (CT) identified a tumor in the common bile duct. The patient underwent successful radical pancreaticoduodenectomy, and postoperative histopathological analysis confirmed carcinosarcoma with predominant sarcomatoid differentiation. This report underscores the diagnostic challenges and therapeutic considerations for this rare entity, emphasizing the critical role of pathological confirmation.

Frontiers in OncologyVol. 15
Inner Mongolia People's Hospital (CN), Beijing Friendship Hospital (CN), Inner Mongolia Medical University (CN)
Openalex Percentile: Top 68%
Metastasis and carcinoma case studies
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Case Report: Carcinosarcoma of the common bile duct: a rare case report with literature review — Julia Lou, Haoyu Fang, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS