Exploring the role of circ-GALK2 in vascular smooth muscle cell calcification: mechanisms and implications
The current study elucidates the unique expression and critical function of the circ-GALK2/miR-134-3p/CD36 axis in vascular smooth muscle calcification, potentially offering significant insights for developing strategies to mitigate the progression of vascular calcification disease. Furthermore, this axis is anticipated to serve as a biomarker and a prospective therapeutic target for vascular calcification.
Authors
- Ying Sheng
- Ruijiao Kong (ORCID: https://orcid.org/0000-0002-9784-8926)
- Gangjun Zong
- Tianhui Jin
- Huijun Li (ORCID: https://orcid.org/0000-0002-2896-3867)
- Yehong Liu (ORCID: https://orcid.org/0000-0002-1211-2961)
- Li Wang (ORCID: https://orcid.org/0000-0003-3722-5986)
- Liang Chen (ORCID: https://orcid.org/0000-0003-4760-5165)
- Xinyi Hu (ORCID: https://orcid.org/0009-0002-7291-2095)
Institutions
- Tongji University (CN)
- Shanxi Medical University (CN)
- 81th Hospital of PLA (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s40001-025-03040-1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province