Hepatic Inflammation and Liver Injury in a Model of Bacterial Infection Triggered Acute‐on‐Chronic Liver Injury
Differential expression of hepatic cytokines and chemokines in Abcb4<sup>-/-</sup> mice upon LPS challenge provides insight into potential mediators of disease progression in this dual-hit model of BI-ACLI. Our findings suggest that increased expression of IL-6, IL-2, IL-22, and RANTES may be associated with inflammatory responses that contribute to disease exacerbation in this refined model.
Authors
- Frank Lammert (ORCID: https://orcid.org/0000-0003-4450-7201)
- SN Weber
- Mathias Hohl (ORCID: https://orcid.org/0000-0001-6946-9825)
- Leonard Kaps (ORCID: https://orcid.org/0000-0002-4782-8003)
- Senem Ceren Karataylı (ORCID: https://orcid.org/0000-0002-2052-9281)
- Ersin Karataylı (ORCID: https://orcid.org/0000-0002-7878-6520)
- Jörn M. Schattenberg (ORCID: https://orcid.org/0000-0002-4224-4703)
- R. A. Hall
Institutions
- Medizinische Hochschule Hannover (DE)
- Saarland University (DE)
Publication Details
- Journal
- Journal of Gastroenterology and Hepatology
- Published
- 2025-08-17
- DOI
- https://doi.org/10.1111/jgh.70055
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35