Electrochemical biosensor with custom fluidics for amplification-free, low-picomolar DNA detection
This study represents a notable advancement in electrochemical biosensing, introducing a modular, amplification-free platform capable of highly sensitive DNA detection in both buffer solutions and complex biological samples. Its low cost, operational simplicity, and reliable performance in real-world matrices make it a promising candidate for point-of-care applications. This approach offers a practical alternative for molecular diagnostics and monitoring in clinical, environmental, and industrial contexts.
Authors
- Bartolomeo Della Ventura (ORCID: https://orcid.org/0000-0003-2920-6187)
- Stefano Mazzoleni (ORCID: https://orcid.org/0000-0002-1132-2625)
- Maria De Luca (ORCID: https://orcid.org/0000-0002-4154-1415)
- Raffaele Velotta (ORCID: https://orcid.org/0000-0003-1077-8353)
- Elisabetta de Alteriis (ORCID: https://orcid.org/0000-0002-5874-3961)
- Vincenzo Iannotti (ORCID: https://orcid.org/0000-0001-7229-5045)
- Fabrizio Cartenì (ORCID: https://orcid.org/0000-0001-8985-1132)
- Tina D’Aponte (ORCID: https://orcid.org/0009-0002-6598-7478)
Institutions
- Federico II University Hospital (IT)
- Department of Agricultural Sciences (RU)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.aca.2025.344554
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- European Commission
- Ministero dell'Università e della Ricerca