Spatial heterogeneity reveals an evolutionary signature predicting therapeutic response and clinical outcomes in hepatocellular carcinoma
Our study reveals that regional transcriptional heterogeneity within tumors is substantial enough to capture survival signals, and the constructed and validated HCCEvoSig provides reliable prognostic information for HCC patients.
Authors
- Yajing Zhang (ORCID: https://orcid.org/0009-0007-2285-3775)
- Jian Shi (ORCID: https://orcid.org/0000-0001-5802-7116)
- Shangyi Luo (ORCID: https://orcid.org/0000-0002-0254-8593)
- Li Liu (ORCID: https://orcid.org/0000-0002-5641-446X)
- Yang Sun
Institutions
- Fujian Medical University (CN)
- Harbin Medical University (CN)
- Fuzhou University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fbinf.2025.1669236
- Primary Topic
- Evolution and Genetic Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00