Vaginal microbiota: different roles of lactobacilli and community instability in chronic vulvovaginal discomfort
Our results revealed an opposing trend in the abundance of <i>L. iners</i> and <i>L. gasseri</i> between CVD patients and healthy controls, depending on CST stability. We hypothesize that the increased prevalence of CST2 and CST3 may result either from persistent CVD-associated pressure (CST2 and partially CST3), or from enhanced community stability (CST3). The finding that the importance and behavior of <i>Lactobacillus</i> species depend on the patient's clinical status and microbiota context (CST) should contribute to more accurate diagnoses (correct interpretation of laboratory findings) and management of CVD.
Authors
- Zuzana Uhlířová
- Vladimı́r Buchta
- Radka Bolehovská
- H Skalská (ORCID: https://orcid.org/0000-0002-4837-711X)
- Daniel Leško
- Alena Mrkvicová (ORCID: https://orcid.org/0000-0001-7802-5564)
- Ctirad Andrýs (ORCID: https://orcid.org/0000-0001-6489-8786)
- Marián Kacerovský (ORCID: https://orcid.org/0000-0001-9858-7900)
- Lenka Plíšková
- Filip Vrbacký (ORCID: https://orcid.org/0000-0001-9880-117X)
- Jana Nekvindová (ORCID: https://orcid.org/0000-0002-2861-5483)
- Peter Veščičík
- Jiří Špaček (ORCID: https://orcid.org/0000-0003-4887-3196)
Institutions
- University Hospital Hradec Králové (CZ)
- University of Hradec Králové (CZ)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fcimb.2025.1636873
- Citations
- 5
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.34