Immune counter-evolution: immortalized B cell clones can undergo ex vivo directed evolution to counteract viral escape
Our findings illustrate the use of immortalized B cell libraries for development of therapeutics that adapt to viral evolution and highlight the application of ex vivo directed evolution in refining antibody responses against emerging immune escape SARS-CoV-2 variants. The approach here described offers a promising pathway for rapid therapeutic development in the face of evolving viral threats.
Authors
- Casper Marsman (ORCID: https://orcid.org/0000-0002-3007-5105)
- Vanessa Clerico Mosina (ORCID: https://orcid.org/0000-0001-8013-0144)
- Jurgen Heinen
- Arjen Q. Bakker
- Stefano V. Gullà
- Kelly Maijoor
- Alessandra Villa
- Michael Koslowski
Institutions
- Atara Biotherapeutics (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1648717
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00