Re-starting or initiating guideline-recommended hypoglycemic agents for patients admitted with hyperglycemic crisis
The study suggests that early initiation of non-insulin hypoglycemic results in similar delta BG compared to late initiation following acute management of DKA and HHS. The findings indicate that early transitioning to non-insulin hypoglycemic agents is associated with a lower 90-day mortality rate after acute management of DKA/HHS and a strong predictor for shorter hospital LOS. Further research, including randomized controlled trials, is recommended to validate these findings and explore long-term effects on mortality and clinical outcomes.
Authors
- Abdulrahman I. Alshaya
- Abdulmajeed M. Alshehri (ORCID: https://orcid.org/0000-0002-9104-5727)
- Omar A. Alshaya (ORCID: https://orcid.org/0000-0002-2244-0491)
- Mohammed Alrashed (ORCID: https://orcid.org/0000-0002-5203-8962)
- Hisham A. Badreldin
- Lama Alfehaid (ORCID: https://orcid.org/0000-0002-1549-0941)
- Haya Al-Yahya
Institutions
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Abdulaziz Medical City (SA)
- King Abdullah International Medical Research Center (SA)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fmed.2025.1485357
- Primary Topic
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Type
- article
- Field-Weighted Citation Impact
- 0.00