Curious case of swelling in the thigh: Benign granular cell tumor

Granular cell tumors (GCTs), also known as Abrikossoff tumors, are rare soft tissue neoplasms originating from Schwann cells. Although typically benign, they can present as a diagnostic challenge due to their non-specific clinical and radiological features. We report the case of a 52-year-old male who presented with an 8-month history of progressively enlarging swelling in the left thigh. Histopathological examination confirmed the diagnosis of a GCT, characterized by round-to-polygonal cells with mild nuclear atypia and abundant eosinophilic cytoplasm containing coarse granules. Immunohistochemical staining revealed strong positivity for inhibin and SOX 10 - SRY (Sex determining Region Y) -Box 10, which further supported the diagnosis. Due to involvement of the surgical margins, the patient underwent wide local excision of the tumor. Although GCTs do not present with characteristic features, they should be considered in the differential diagnosis of long-standing soft tissue swellings.