FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2
FASN promotes CRC progression by enhancing CSC stemness and suppressing ferroptosis through SREBP2 inhibition, highlighting its potential as a therapeutic target.
Authors
- Binbin Su (ORCID: https://orcid.org/0000-0003-1814-024X)
- Cheng Wu (ORCID: https://orcid.org/0000-0002-1100-3122)
- Hui Shi (ORCID: https://orcid.org/0000-0002-0104-8212)
- Ming Wang (ORCID: https://orcid.org/0009-0001-1922-6363)
- Xiaoyu Dong (ORCID: https://orcid.org/0000-0003-0678-4056)
- Shiping Xu
- Fulin Ge
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1611375
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52