A genome-wide association study identifies new loci associated with response to SARS-CoV-2 mRNA-1273 vaccine in a cohort of healthy healthcare workers
In conclusion, this study highlights the complex interplay of genetic factors influencing the immune response to vaccination, particularly through modulation of B cell activity, immune signaling pathways, and metabolic processes. The identification of genetic variants could inform future strategies to enhance vaccine efficacy and provide a deeper understanding of individual variability in vaccine responses, especially for COVID-19 and other viral infections.
Authors
- Juan Sáinz (ORCID: https://orcid.org/0000-0002-9355-2423)
- Fernando J. Reyes‐Zurita (ORCID: https://orcid.org/0000-0003-3438-0753)
- Rob ter Horst (ORCID: https://orcid.org/0000-0003-0576-5873)
- Antonio José Cabrera-Serrano (ORCID: https://orcid.org/0000-0003-0346-7960)
- Antonio Sampedro
- Mihai Gheorghe Netea (ORCID: https://orcid.org/0000-0003-2421-6052)
- Francisco José García‐Verdejo (ORCID: https://orcid.org/0009-0004-0863-016X)
- Juan Francisco Gutiérrez‐Bautista (ORCID: https://orcid.org/0000-0003-1374-0756)
- Pedro Sánchez‐Rovira (ORCID: https://orcid.org/0000-0003-2658-1467)
- Miguel Ángel López‐Nevot (ORCID: https://orcid.org/0000-0002-3465-6062)
- Li Yang (ORCID: https://orcid.org/0000-0002-4710-059X)
- María Carretero-Fernández
- Lucía Ruiz-Durán
Institutions
- University of Bonn (DE)
- Radboud University Nijmegen (NL)
- Austrian Research Institute for Artificial Intelligence (AT)
- Universidad de Granada (ES)
- Radboud University Medical Center (NL)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Complejo Hospitalario de Jaén (ES)
- CeMM Research Center for Molecular Medicine (AT)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Centre for Individualised Infection Medicine (DE)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Life & Brain (Germany) (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fimmu.2025.1639825
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Radboud Universiteit
- Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológic