Exosomal miR-93-3p targets EIF4EBP1 to regulate macrophage polarization and accelerate wound healing post-anal fistula surgery
This study is the first to elucidate the molecular mechanism by which the TCM therapeutic approach of Euriching Pus for Tissue Growth promotes M2 MP through the exosomal miR-93-3p/EIF4EBP1 axis, and theoretically supports the formulation of new exosome-based miRNA treatment strategies for postoperative anti-inflammatory treatment in AF.
Authors
- Ruoxi Cao
- Wei Zhang (ORCID: https://orcid.org/0000-0002-8706-6082)
- Xi Chen (ORCID: https://orcid.org/0009-0005-2765-6653)
- Junhong Chen (ORCID: https://orcid.org/0000-0002-9143-1222)
- Wenzhe Feng
Institutions
- Affiliated Hospital of Shaanxi University of Chinese Medicine (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fphar.2025.1599633
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China