2-Deoxy-D-Glucose and ES-936 sensitize cancer- but not normal cells to both low- and high LET irradiation
Our results imply that distinct mechanisms influence the clonal survival and DNA repair of irradiated, inhibitor-treated cancer cells in dependence of the LET. The findings of this study suggest that the combination of inhibitors targeting glycolysis and the redox balance may represent a promising strategy to enhance the sensitivity of cancer cells to both photon- and charged particle therapy.
Authors
- Burkhard Jakob (ORCID: https://orcid.org/0000-0003-2404-377X)
- Henrieke Förster
- Kris Kratz
- Marco Durante (ORCID: https://orcid.org/0000-0002-4615-553X)
- K. Vogel
Institutions
- GSI Helmholtz Centre for Heavy Ion Research (DE)
- Technische Universität Darmstadt (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fonc.2025.1633299
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Philipps-Universität Marburg
- Bundesministerium für Bildung und Forschung
- GSI Helmholtzzentrum für Schwerionenforschung