Longitudinal association between somatic symptoms and suicidal ideation in adults with major depressive disorder
Our findings suggest that in patients with MDD, there is a significant association between somatic symptoms and their subtypes with SI. Notably, the risk of SI is significantly increased by somatic symptoms in a nonlinear manner. These findings highlight the necessity of addressing somatic symptoms in the management of depression and emphasize the importance of developing targeted interventions to mitigate suicide risk in this vulnerable population.
Authors
- Wenjing Zhou (ORCID: https://orcid.org/0000-0002-7272-6236)
- Qindan Zhang
- Beifang Fan (ORCID: https://orcid.org/0000-0003-4241-2997)
- Lan Guo (ORCID: https://orcid.org/0000-0002-5213-2158)
- Yuhua Liao (ORCID: https://orcid.org/0000-0002-5006-6644)
- Huimin Zhang (ORCID: https://orcid.org/0000-0001-9523-2215)
- Hao Zhao (ORCID: https://orcid.org/0000-0003-2063-4652)
- Ciyong Lu (ORCID: https://orcid.org/0000-0003-4266-4967)
- Yanzhi Li (ORCID: https://orcid.org/0000-0001-7436-2440)
- Wanxin Wang (ORCID: https://orcid.org/0000-0003-4979-9514)
- Roger S. McIntyre
- Subinuer Yiming
- Ruiying Chen (ORCID: https://orcid.org/0000-0003-2556-7604)
- Yifeng Liu (ORCID: https://orcid.org/0009-0009-0097-9873)
- Christine E. Dri
Institutions
- Sun Yat-sen University (CN)
- Zunyi Medical University (CN)
- University of Toronto (CA)
- Brain and Cognition Discovery Foundation (CA)
- Shenzhen Nanshan Center for Chronic Disease Control (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fpsyt.2025.1634899
- Citations
- 2
- Primary Topic
- Suicide and Self-Harm Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Sanming Project of Medicine in Shenzhen