Case Report: Concurrent retinal vasculitis and optic neuritis in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect the ocular system, with retinal vasculitis and optic neuritis being rare but serious manifestations. We present a case of a 26-year-old female with newly diagnosed SLE who developed both retinal vasculitis and optic neuritis, leading to progressive visual impairment. She was successfully treated with methylprednisolone and rituximab, achieving significant visual recovery. A review of existing literature highlights the diagnostic challenges, pathophysiology, and optimal treatment strategies for such cases. Our findings emphasize the importance of early recognition and aggressive immunosuppressive therapy in improving patient outcomes.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-08-18
DOI
https://doi.org/10.3389/fimmu.2025.1646850
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Case Report: Concurrent retinal vasculitis and optic neuritis in systemic lupus erythematosus

Longjiang Fang, Di Jin, Wanyun Nie, Ming Li et al.
Frontiers in Immunology
Systemic Lupus Erythematosus Research
article

Case Report: Concurrent retinal vasculitis and optic neuritis in systemic lupus erythematosus

Longjiang Fang, Di Jin, Wanyun Nie, Ming Li, Yang Liu, Sheng‐Guang Li, Chen Li, Yu Wang
article en

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect the ocular system, with retinal vasculitis and optic neuritis being rare but serious manifestations. We present a case of a 26-year-old female with newly diagnosed SLE who developed both retinal vasculitis and optic neuritis, leading to progressive visual impairment. She was successfully treated with methylprednisolone and rituximab, achieving significant visual recovery. A review of existing literature highlights the diagnostic challenges, pathophysiology, and optimal treatment strategies for such cases. Our findings emphasize the importance of early recognition and aggressive immunosuppressive therapy in improving patient outcomes.

Frontiers in ImmunologyVol. 16
Tianjin University of Traditional Chinese Medicine (CN), Beijing University of Chinese Medicine (CN), Peking University (CN), Weifang People's Hospital (CN), Peking University International Hospital (CN), Tianjin Hospital (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 67%
Systemic Lupus Erythematosus Research
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