Impact of 2D versus 3D fibroblast models on Leishmania species invasion in vitro: Rab5 dynamics and actin activity in initial infection
These novel findings reveal that distinct Leishmania species utilize specialized invasion strategies, adapting to both host cell type and experimental conditions. This underscores the role of species-specific biological traits in modulating host cell entry mechanisms, which may, in turn, influence the varied clinical manifestations associated with each species.
Authors
- Rebecca Thereza Silva Santa Brígida
- Ana Paula Rodrigues (ORCID: https://orcid.org/0000-0002-5016-392X)
- Brenda Furtado Costa
- Felipe Tuji de Castro Franco
- Adeniele Lopes da Cruz Carneiro
Institutions
- Universidade do Estado do Pará (BR)
- Instituto Evandro Chagas (BR)
- Universidade Federal do Pará (BR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.3389/fcimb.2025.1654654
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior