Liraglutide attenuates doxorubicin-induced cardiomyocyte ferroptosis via DHHC7-mediated STAT3 palmitoylation
We demonstrate a novel cardioprotective axis wherein liraglutide enhances DHHC7-dependent STAT3 palmitoylation, facilitating its phosphorylation, nuclear translocation, and transcriptional activation of GPX4 to suppress ferroptosis. This study provides the first evidence that DHHC7-mediated STAT3 palmitoylation is essential for liraglutide's efficacy, identifying a promising therapeutic target for DOX cardiotoxicity.
Authors
- Lihong Shi (ORCID: https://orcid.org/0009-0006-9229-1483)
- Ge Gao (ORCID: https://orcid.org/0000-0003-3328-2879)
- Yu Jiang (ORCID: https://orcid.org/0000-0003-0716-4334)
- Cuiling Ji
- Fang Fang (ORCID: https://orcid.org/0000-0002-5272-302X)
- Cheng Shen (ORCID: https://orcid.org/0000-0001-5037-1270)
- Wenqiang Chen (ORCID: https://orcid.org/0000-0002-0350-1383)
- Manman Wang (ORCID: https://orcid.org/0000-0003-4936-7674)
- Jinguo Zhang (ORCID: https://orcid.org/0000-0003-4604-9961)
Institutions
- Weifang Medical University (CN)
- Qilu Hospital of Shandong University (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Jining Medical University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.lfs.2025.123912
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04