Tumor Mutational Burden as a Prognostic Biomarker for Relapse-Free Survival in Hepatocellular Carcinoma: Insights from Long-Term Follow-Up
High TMB is associated with shorter RFS in HCC, particularly among patients with long-term follow-up, indicating an increased risk for multicentric recurrence. TMB may serve as a valuable prognostic biomarker for recurrence risk stratification. The associations between TMB, liver fibrosis, and inflammation suggest potential therapeutic strategies targeting the hepatic microenvironment to reduce recurrence risk in patients undergoing liver resection for HCC.
Authors
- Ken D Yamaguchi (ORCID: https://orcid.org/0000-0002-7669-1405)
- Katsuhiko Uesaka (ORCID: https://orcid.org/0000-0002-9983-1730)
- Kenichi Urakami (ORCID: https://orcid.org/0000-0002-4751-0978)
- Hideyuki Dei (ORCID: https://orcid.org/0000-0002-5091-5036)
- Ryo Ashida (ORCID: https://orcid.org/0000-0001-8388-0135)
- Yukiyasu Okamura (ORCID: https://orcid.org/0000-0003-3384-2709)
- Teiichi Sugiura (ORCID: https://orcid.org/0000-0001-7163-4084)
- Yoshiyasu Kato (ORCID: https://orcid.org/0000-0002-2203-256X)
- Shimpei Otsuka (ORCID: https://orcid.org/0000-0002-2450-3011)
- Takeshi Nagashima (ORCID: https://orcid.org/0000-0002-7261-9908)
- Keiichi Hatakeyama (ORCID: https://orcid.org/0000-0001-6000-5899)
- Yuya Miura (ORCID: https://orcid.org/0000-0003-0461-4109)
- Yasuto Akiyama (ORCID: https://orcid.org/0000-0003-3813-7726)
- Keiichi Ohshima (ORCID: https://orcid.org/0000-0002-2882-7566)
- Katsuhisa Ohgi (ORCID: https://orcid.org/0000-0003-1647-1117)
Institutions
- Nihon University (JP)
- Shizuoka Cancer Center (JP)
- SRL (Japan) (JP)
Publication Details
- Journal
- Liver Cancer
- Published
- 2025-08-15
- DOI
- https://doi.org/10.1159/000547996
- Citations
- 1
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.32