Plasma IL-6 Levels as a Biomarker for Behavioral Changes in Alzheimer’s Disease
Peripheral IL-6 is significantly associated with BPSD severity in AD, independently of central inflammatory markers. This finding suggests a distinct peripheral immune mechanism underlying neuropsychiatric symptoms, potentially mediated through systemic pathways such as vagus nerve signaling or gut-brain-immune interactions. Peripheral IL-6 may serve as a clinically relevant biomarker and therapeutic target for behavioral disturbances in AD.
Authors
- Takeshi Ikeuchi (ORCID: https://orcid.org/0000-0001-8828-8085)
- Akinori Takeda (ORCID: https://orcid.org/0000-0002-8673-8772)
- Yasuyuki Kimura (ORCID: https://orcid.org/0000-0002-7927-9483)
- Nobuyoshi Shimoda (ORCID: https://orcid.org/0000-0003-0321-8905)
- Aya Ogata (ORCID: https://orcid.org/0000-0002-6474-6229)
- Fumihiko Yasuno (ORCID: https://orcid.org/0000-0002-5981-5795)
- Kengo Ito (ORCID: https://orcid.org/0000-0002-5700-688X)
- Kensaku Kasuga (ORCID: https://orcid.org/0000-0002-2178-0769)
- Kastunori Yokoi
- Takashi Sakurai (ORCID: https://orcid.org/0000-0002-2369-3095)
- Hiroshi Ikenuma
- Yumeka Yamauchi
- Takashi Kato (ORCID: https://orcid.org/0000-0002-4293-4333)
- Atsushi Watanabe (ORCID: https://orcid.org/0000-0001-9143-3079)
- Takashi Nihashi (ORCID: https://orcid.org/0000-0002-5544-7649)
- Junichiro Abe
- Hiroyuki Minami
Publication Details
- Journal
- NeuroImmunoModulation
- Published
- 2025-08-16
- DOI
- https://doi.org/10.1159/000547726
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16