Imogolite nanotube modifications impact pulmonary toxicity in mice: implications for safe and sustainable by design (SSbD)
Both imogolite variants induced pulmonary inflammation and an acute-phase response in mice; however, these effects were markedly reduced for the methylated imogolite (Imo-CH<sub>3</sub>). In addition to surface functionalization, factors like bundle formation and by-product particles may also influence toxicity. These findings emphasize the pivotal role of surface chemistry-and associated structural properties-in shaping the biological response to nanomaterials, reinforcing the need for thoughtful design strategies to promote safer applications in nanotechnology.
Authors
- Ulla Vogel (ORCID: https://orcid.org/0000-0001-6807-1524)
- Dorra Gargouri (ORCID: https://orcid.org/0000-0002-5428-5633)
- Fabienne Testard (ORCID: https://orcid.org/0000-0002-5603-9516)
- Arianna Filoramo (ORCID: https://orcid.org/0000-0003-3300-9493)
- Pekka Kohonen (ORCID: https://orcid.org/0000-0002-7845-3611)
- Pernille Høgh Danielsen (ORCID: https://orcid.org/0000-0001-7212-7818)
- Sarah Søs Poulsen (ORCID: https://orcid.org/0000-0001-7456-0017)
- Alicja Mortensen (ORCID: https://orcid.org/0000-0001-6992-7750)
- Trine Berthing (ORCID: https://orcid.org/0000-0003-0723-9869)
- Roland C. Grafström (ORCID: https://orcid.org/0000-0003-2273-3128)
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Turku (FI)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Karolinska Institutet (SE)
- CEA Paris-Saclay (FR)
- National Research Centre for the Working Environment (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12951-025-03647-w
- Citations
- 2
- Primary Topic
- Immunotoxicology and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Research Centre
- European Commission