UMI-77 targets MCL-1 to activate mitophagy and ameliorate periodontitis in mice
UMI-77, especially with local high-dose administration, offers a new, potentially effective and safe approach for periodontitis treatment, holding great promise for clinical translation.
Authors
- Hom‐Lay Wang (ORCID: https://orcid.org/0000-0003-4238-1799)
- Chu‐Mei Lan (ORCID: https://orcid.org/0000-0003-3451-1151)
- Shu Ouyang
- Jingjing Yan (ORCID: https://orcid.org/0000-0002-0654-2543)
- Liangjun Zhong (ORCID: https://orcid.org/0000-0001-6225-4784)
- Dalei Sun (ORCID: https://orcid.org/0000-0003-4280-4042)
- Xiaoxuan Xu (ORCID: https://orcid.org/0000-0003-2223-5778)
- Jun Lin (ORCID: https://orcid.org/0000-0001-5667-4328)
- Wubin Ouyang (ORCID: https://orcid.org/0009-0003-3599-7672)
Institutions
- Affiliated Hospital of Hangzhou Normal University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1016/j.imbio.2025.153108
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71