Periodontitis in patients with severe erectile dysfunction undergoing penile prosthesis implantation: Clinical and immunohistochemical study

Erectile dysfunction (ED) is a common condition where men have trouble achieving or maintaining an erection. In severe cases, surgery to implant a penile prosthesis is sometimes needed. This study explored whether gum disease (periodontitis), a condition that damages the tissues supporting the teeth, is linked to severe erectile dysfunction (SED). We compared two groups of patients: those with SED who required a penile implant and those with other penile conditions, such as curvature. We found that men with SED were more likely to have advanced gum disease, fewer teeth, and signs of poor oral health. They also showed lower levels of certain molecules, like nitric oxide, that help blood vessels work properly, including those in the penis. Diabetes and being older than 55 also increased the likelihood of SED. Our findings suggest that gum disease may play a role in SED, possibly by affecting blood vessel health. This highlights the importance of good oral hygiene and managing conditions like diabetes to support overall health. These results may help guide healthcare providers in preventing or treating erectile dysfunction in men with periodontitis.