Blockade of the Notch Pathway by Inhibition of Fucosylation Ameliorates Chondrocyte Inflammation and Extracellular Matrix Degradation
Inhibition of fucosylation can ameliorate chondrocyte inflammation and extracellular matrix degradation by decreasing Notch1 activity and down-regulating the expression of the Notch pathway, which can effectively alleviate the development of OA.
Authors
- Feng Tian (ORCID: https://orcid.org/0000-0002-6598-419X)
- N. Li
- Xin Chang (ORCID: https://orcid.org/0009-0006-3547-7492)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-1381-8958)
- Yi Li (ORCID: https://orcid.org/0009-0008-7752-0158)
- Xiaodong Wen
- Liu C (ORCID: https://orcid.org/0000-0002-2219-1018)
- Junkui Xu
- Maorong Liu
- Yunheng Zhang
Institutions
- Xi'an Honghui Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-08-01
- DOI
- https://doi.org/10.2147/jir.s520179
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00