Hypotentive and Antihypertentive Effect of Leaves Aqueous Extract of <i>Saccharum officinarum</i>(Poaceae) on Rabbits

Saccharum officinarum L. (Poaceae) is a plant used in traditional medicine to treat high blood pressure. In order to provide a scientific basis, this study was undertaken. Thus, we carried out a study of the antioxidant activity and pharmacological tests on the leaves aqueous extract of Saccharum officinarum L. (Poaceae). The DPPH test showed that Esol contains antioxidants with an IC50 of 0.5211 mg/mL. Pharmacological effects showed that Esol induced dose-dependent hypotension at doses ranging from 1 mg/kg B.W. to 20 mg/kg B.W., with a 50% Effective Dose of 5.17 mg/kg B.W. Interactions between the extract and pharmacological substances revealed that atropine had no significant effect (p > 0.05) on Esol-induced hypotension. The extract significantly reduced and cancelled (p Saccharum officinarum in the treatment in cardiovascular disorders.