Spatially resolved analysis of TGF/BMP signalling in pancreatic ductal adenocarcinoma by digital pathology identifies patient subgroups with adverse outcome
Our spatial analysis reveals intratumoural heterogeneity of TGF/BMP signalling and its significance for PDAC progression. Notably, stromal TGF-B2 emerges as a prognostic biomarker, while TGF-B1 and ID1 are implicated in adverse clinical and pathologic features. These findings highlight the importance of TGF/BMP signalling niches in the TME with implications for PDAC biology and can inform the development of future therapeutic strategies.
Authors
- Viktor Hendrik Koelzer (ORCID: https://orcid.org/0000-0001-9206-4885)
- Janine Rohrbach
- Stefan Reinhard (ORCID: https://orcid.org/0000-0001-7272-7792)
- Beat Gloor (ORCID: https://orcid.org/0000-0003-2135-605X)
- Konstantin Bräutigam (ORCID: https://orcid.org/0000-0002-3966-3579)
- Anna S. Wenning (ORCID: https://orcid.org/0000-0001-7684-6481)
- Philipp Zens
- Martin Wartenberg (ORCID: https://orcid.org/0000-0002-5378-3825)
- Simon J. Leedham (ORCID: https://orcid.org/0000-0003-1476-6982)
Institutions
- University of Bern (CH)
- Centre for Human Genetics (GB)
- Institute of Cancer Research (GB)
- University of Basel (CH)
- University of Zurich (CH)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
- John Radcliffe Hospital (GB)
- National Institute for Health and Care Research (GB)
- University of Oxford (GB)
- University Hospital of Zurich (CH)
- NIHR Biomedical Research Centre at The Royal Marsden and the ICR
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-18
- DOI
- https://doi.org/10.1186/s12885-025-14751-3
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Science Foundation
- University of Bern
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung