Potential Drug Dose‐Specific Adverse Three‐Drug Combinations: A <scp>US</scp> Insurance Claims Data‐Based Study
Use of three-drug combinations is increasingly prevalent and associated with an increased risk of adverse drug events (ADEs). We identified potential adverse three-drug combinations from real-world data, and revealed the corresponding relationships between doses and risks of ADEs. We find doses might be used to evaluate the risk of ADE for many adverse three-drug combinations. Additionally, we find risk of many adverse three-drug combinations might be decreased by reducing the dose of one drug without any drug discontinuation.
Authors
- Jeffrey M. Caterino (ORCID: https://orcid.org/0009-0004-2512-4955)
- Macarius M. Donneyong (ORCID: https://orcid.org/0000-0003-2710-913X)
- Katherine M. Hunold (ORCID: https://orcid.org/0000-0001-8938-0596)
- Ping Zhang (ORCID: https://orcid.org/0000-0002-4601-0779)
- C. W. Chiang
- Michael T. Eadon (ORCID: https://orcid.org/0000-0003-3066-2876)
- Jie Xu (ORCID: https://orcid.org/0000-0002-5059-3671)
- Massimiliano Russo (ORCID: https://orcid.org/0000-0003-4953-9341)
- Ling Li (ORCID: https://orcid.org/0000-0002-1642-142X)
- Yang Yue (ORCID: https://orcid.org/0000-0002-6102-9240)
- Alfred Xuyang Sun (ORCID: https://orcid.org/0000-0002-7893-2006)
- Jianhua Su (ORCID: https://orcid.org/0000-0002-6621-180X)
- Yi Shi (ORCID: https://orcid.org/0000-0003-0145-2968)
Institutions
- Indiana University Indianapolis (US)
- Indiana University School of Medicine
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2025-08-17
- DOI
- https://doi.org/10.1002/pds.70199
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health